Loading...

Mercury disrupting metabolism and altering gene expression - Hallo friend HEALTHY LIVING, In the article you read this time with the title Mercury disrupting metabolism and altering gene expression, we have prepared well for this article you read and download the information therein. hopefully fill posts items ENTERTAINMENT, items FITNES, items HEALTHY, items HEALTHY FOOD, items HEALTHY LIVING, items HOW HEALTHY, we write this you can understand. Well, happy reading.

Title : Mercury disrupting metabolism and altering gene expression
link : Mercury disrupting metabolism and altering gene expression

Mercury disrupting metabolism and altering gene expression

The Watchers | Aug 15, 2017

The mercury found at very low concentrations in water is concentrated along the entire food chain, from algae via zooplankton to small fish and on to the largest fish -- the ones we eat. Mercury causes severe and irreversible neurological disorders in people who have consumed highly contaminated fish. Whereas we know about the element's extreme toxicity, what happens further down the food chain, all the way down to those microalgae that are the first level and the gateway for mercury? By employing molecular biology tools, a team of researchers from the University of Geneva (UNIGE), Switzerland, has addressed this question for the first time. The scientists measured the way mercury affects the gene expression of algae, even when its concentration in water is very low, comparable to European environmental protection standards.

The UNIGE research team is led by Vera Slaveykova, professor of environmental biogeochemistry and ecotoxicology in the Department F.A. Forel for environmental and aquatic sciences, and vice-president of the School of Earth and environmental sciences, Faculty of Sciences of the UNIGE. The scientists selected a green microalga measuring barely six microns by ten, known as Chlamydomonas reinhardtii. The alga was chosen not because of its colour or the two flagella it uses to swim but because, of all the primary producers in the aquatic environment at the the lowest level of the food chain of the food chain, it is the one whose genome has been fully sequenced. The availability of this genomic information made it possible to compare gene expression of algae exposed to different concentrations of mercury and to determine the associated effects.

Mercury disrupts the metabolism of algae

The researchers were able to analyse the transcriptome of the microalgae - i.e. the set of all RNA molecules that controls the expression of their genes - using molecular biology tools. As professor Slaveykova explains: "We were able to accurately determine which were over-expressed or, on the contrary, under-expressed as a result of exposure to mercury." And the conclusion was clear: mercury disrupted the metabolism of algae, with numerous genes being deregulated, regardless of whether the concentrations were comparable with those set by European environmental standards, lower or higher than those usually found in the environment.

An alga that seems healthy from a physiological point of view appears altered when its gene's expression is examined. The dysregulated genes are involved in diverse processes, from the generation of reactive oxygen species triggering antioxidant defence to the alteration of the flagella and cell motility. The photosynthesis and transport of essential elements such as zinc, iron or copper are also affected. It is difficult, however, to establish an exhaustive list since, as professor Slaveykova points out: "Of the 5,493 genes specifically dysregulated by methylmercury, we don't yet know the function of 3,569 of them, even though this alga is the most widely studied of all the primary producers". Together with inorganic mercury, methylmercury is one of two forms of the element analysed by the researchers. It is formed by the transformation of inorganic mercury caused by bacteria in the anoxic environment. It magnifies in the food chain and can directly affect the central nervous system of the top consumers.

The accumulation of mercury in fish, together with its impact on human health, have been the subject of numerous studies since the Minamata disaster, when the population of this eponymous Japanese fishing harbour was hit by large-scale pollution in the mid-twentieth century. However, thanks to the transcriptomic approach adopted by the UNIGE researchers, we now know how mercury enters the food chain and affects the microalgae at its base.

An environmental and public health issue

Although mercury is found naturally in the environment (it is emitted, for example, when a volcano erupts), its concentration has been steadily increasing because of human activity: by burning coal or releasing mercury as part of various industrial processes. It is now estimated that over half the mercury in the air is linked to human activities, and that the ratio is nearly two-thirds in the aquatic environment. And it is a global problem since high levels of mercury have been detected in the blood of polar bears, far from any source of contamination. It is crucial, therefore, that we understand the governing mechanisms, both from an environmental and public health perspective.

Source: Université de Genève

Featured image: Green microalga Chlamydomonas reinhardtii, a model system for molecular biology and environmental studies. Image © Dartmouth College Electron Microscope Facility, Louisa Howard

Loading...

thus Article Mercury disrupting metabolism and altering gene expression

that is all articles Mercury disrupting metabolism and altering gene expression This time, hopefully can provide benefits to all of you. Okay, see you in another article posting.

You now read the article Mercury disrupting metabolism and altering gene expression with the link address https://healthylivingsimple.blogspot.com/2017/08/mercury-disrupting-metabolism-and.html

Tweet

Subscribe to receive free email updates: